Fig. 8 | Nature Communications

Fig. 8

From: Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Fig. 8

Schematic of the ‘IM-rich subset’ of lung squamous carcinoma. TNFα activation of the canonical NFκB leads to LUSC cell secretion of chemo-attractant CCL2, which stimulates the bone marrow to release inflammatory monocytes (IMs) into circulation. The IMs bring large payloads of FXIIIA into the tumor microenvironment, leading to cross-linked fibrin, LUSC invadopodia formation and progression

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