Fig. 2
From: Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models
Genome-scale vulnerability screens reveal unique and common targets. a T-cell lymphoma specific vulnerabilities, ranked by Z-score and recurrence. b Corresponding false-discovery rate (FDR) q-values. c Corresponding gene expression level; RPKM, reads per kilobase of transcript, per million mapped reads. d Combined gene expression level and FDR. e Dependency score of MDM2 in TP53 -wild-type versus TP53-mutated cell lines. Comparison is by two-sided t-test with Welch correction. f MDMX dependency score across 391 cancer cell lines with TCL lines highlighted in red. g Knockdown of MDM2 and MDMX in TP53-wild-type cell lines KI-JK and SUP-M2 and TP53-mutated cell line SMZ-1 using GFP-expressing, doxycycline inducible shRNA. Data points indicate mean values with error bars indicating standard error of the mean
