Fig. 9
From: Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
Two possible gating mechanisms of Piezo1. Our study reveals Yoda1 sensitivity of Piezo1 requires the presence of only one Yoda1-sensitive subunit per trimer. This result is consistent with a concerted gating mechanism (a) where all subunits cooperatively gate the pore (blue: resting subunits; magenta: activated subunits). This result is also consistent with a sequential mechanism (b) where the pore fully opens if only one subunit is activated
