Table 1 Global fit results for different gating models
From: Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
Number of contributing subunit(s) | ≥1(α = β = γ = 1)(random mixing) | ≥2(α = 0; β = γ = 1)(random mixing) | 3(α = β = 0; γ = 1)(random mixing) | 3(α = β = 0; γ = 1)(no mixing) |
|---|---|---|---|---|
B max | 4.21 ± 0.32 | 5.00 ± 0.48 | 4.68 ± 0.96 | 6.11 ± 0.75 |
K d | 9.62 ± 1.41 | 7.33 ± 2.35 | 7.40 ± 5.05 | 11.74 ± 2.67 |
R 2 | 0.907 | 0.768 | 0.280 | 0.808 |
