Table 1 AR regulation of splenic B cells is not B cell-intrinsic

From: Testosterone is an endogenous regulator of BAFF and splenic B cell number

Target cell (Cre promoter)

Mean reduction of Ar exon 2 DNA in B cells

P-value

No. of B cells (×106)

P-value

Controls

B-ARKO mice

B cells (Cd79a)

93%

<0.0001

24 ± 4

20 ± 2

0.35

B cells (Cd19)

86%

<0.0001

20 ± 3

20 ± 2

0.88

  1. Presentation of B cell-specific ARKO model, Cre promoter used, AR knockout level in the model (measured as relative level of Ar exon 2 DNA in the B cell compartment), and total number of CD19+ B cells in spleen in male control and B cell-specific ARKO (B-ARKO) mice. n = 11 and 8 (Cd79a-Cre+ controls and corresponding B-ARKO), n = 10 and 11 (Cd19-Cre+ controls and corresponding B-ARKO). Values represent mean ± s.e.m. P-values from Mann–Whitney test.
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