Table 1 Alpha-synuclein-induced channel activity and PTP opening in mitochondrial inner membrane patches

From: α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

 

[−] Control

[+] Control

Monomers

Oligomers

Oligomers + Trolox (in the pipette)

IMM basal membrane conductance [nS]

1.26±0.28

0.24±0.02

0.29±0.12

1.6±0.5

0.52±0.2

Channel occurrence, % of total recordings

27

50

50

100

0

Channel predominant transition size [nS]

0.31±0.16

0.75±0.53

0.46±0.26

0.46±0.15

N/A

PTP occurrence, % of total recordings

10

100

25

85

0

PTP peak conductance [nS]

2.5±1.5

3.1±0.8

1.3±1.3

1.9±0.4

N/A

Time until onset of PTP development [min]

3

1–3

5

9

N/A

  1. IMM: inner mitochondrial membrane; PTP: permeability transition pore
Back to article page