Table 2 Oxidation of amino acids by treatment with α-synuclein

From: α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Accession

Description

Gene

ΣCoverage

Σ# Unique Peptides

Σ# Modified AA

# AAs

MW [kDa]

C

100 M

100 O

500 M

500 O

C

100 M

100 O

500 M

500 O

C

100 M

100 O

500 M

500 O

G3V6D3

ATP synthase subunit beta

Atp5b

58.22

61.81

50.47

55.95

58.22

19

20

16

18

19

1

3

6

4

8

529

56.3

F1LP05/P15999

ATP synthase subunit alpha

Atp5a1

36.89

41.95

39.78

37.79

39.42

14

14

14

12

13

2

3

0

2

3

553

59.8

P04636

Malate dehydrogenase, mitochondrial

Mdh2

44.97

39.64

38.17

32.25

38.46

11

10

9

7

9

2

2

2

2

1

338

35.7

Q66HF1

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ndufs1

33.98

29.16

32.74

31.91

20.77

17

15

15

15

9

1

0

0

1

0

727

79.4

P10860

Glutamate dehydrogenase 1, mitochondrial

Glud1

25.27

31.18

32.44

23.12

27.96

10

11

11

8

10

0

0

1

1

0

558

61.4

  1. C: untreated control; M: monomers; O: oligomers; 100: 100 nM; 500: 500 nM
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