Fig. 2 | Nature Communications

Fig. 2

From: Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade

Fig. 2

PP2A inhibition and PD-1 blockade result in a long-term antitumor antigenic-specific memory of cured animals. a BALB/c mice were inoculated with 0.5 × 106 CT26 cells subcutaneously and treated as above. CR or naive control mice were re-challenged about 60-days after initial implantation with 0.5 × 106 CT26 cells in the thoracic flank in combination with 1.25 × 105 4T1 breast carcinoma cells in the mammillary fat pad. b, c Naive—CT26 (blue), CR—CT26 (red), naive—4T1 (green), CR—4T1 (purple). b Individual and mean tumor growth curves over time. c Quantitation of CT26 and 4T1 tumor volume 18 days after inoculation. (P < 0.0001, one-way ANOVA with Tukey’s multiple comparison test). d Picture of representative naive and CR mouse following inoculation of CT26 and 4T1 tumors

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