Fig. 5
From: X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
The arc–arc interactions in the membrane disruption complex are mediated via an isoleucine zipper. a The 20-meric complex (blue cartoon representation with gray transparent surface rendering) in the asymmetric unit with its 14 bound PA molecules (spheres with carbon in green, oxygen in red, phosphorus in orange). The residues Ile13 and Ile15 are highlighted in pink in the interfaces between constituent arcs that comprise the 20-meric NaD1–PA complex. b A close-up view of one of the isoleucine zippers between two arcs in the 20-meric complex. The seven pairs of isoleucines form a continuous hydrophobic interface between the two arcs as shown by the surface representation in pink
