Fig. 1

CHD4 missense mutations identified in endometrial cancer. Fifty-two reported CHD4 mutations were taken into account4,6,7. Mutations identified in samples with a hypermutation phenotype (multiple mutations in CHD4 and/or mutations in DNA polymerase epsilon) were disregarded. Locations of individual missense mutations are shown by a vertical line. The length of this line represents the frequency with which the affected residue was found mutated. Missense mutations analysed in this study are depicted on top. PHD PHD finger, CD chromodomain