Fig. 2
From: Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
MRI demonstration of blood–brain barrier opening and closure. Axial T1-weighted gadolinium MR images of patient 5 at a baseline, b immediately after stage 2 sonication and blood–brain barrier (BBB) opening, and c at 24 h after procedure. Contrast extravasation within the 10 × 10 × 7 mm3 sonicated volume in the right frontal lobe is seen immediately after the procedure, demonstrating increased BBB permeability. At 24 h after the procedure, there is no significant extravasation of contrast in the area, suggesting BBB closure
