Table 2 Psychometric measures
From: Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Baseline | Stage 1 | Stage 2 | ||||
|---|---|---|---|---|---|---|
1 week | 1 month | 1 week | 1 month | 2 months | ||
MMSE | ||||||
Patient 1 | 20 | 22 | 21 | 22 | 23 | 22 |
Patient 2 | 25 | 23 | 20 | 26 | 29 | 23 |
Patient 3 | 22 | 22 | 19 | 20 | 23 | 18 |
Patient 4 | 25 | 21 | – | – | – | – |
Patient 5 | 21 | 23 | 22 | 25 | 25 | 24 |
Mean (SD) | 22.6 (2.3) | 22.2 (0.8) | 20.5 (1.3) | 23.3 (2.8) | 25.0 (2.8) | 21.8 (2.6) |
ADAS-cog | ||||||
Patient 1 | 19 | 21 | 17 | 22 | 18 | 19 |
Patient 2 | 21 | 16 | 23 | 15 | 12 | 22 |
Patient 3 | 30 | 29 | 32 | 28 | 32 | 25 |
Patient 4 | 19 | 15 | – | – | – | – |
Patient 5 | 19 | 20 | 17 | 15 | 20 | 25 |
Mean (SD) | 21.6 (4.8) | 20.2 (5.5) | 22.3 (7.1) | 20.0 (6.3) | 20.5 (8.4) | 22.8 (2.9) |
GDS | ||||||
Patient 1 | 0 | 0 | 1 | 2 | 2 | 2 |
Patient 2 | 4 | 2 | 4 | 5 | 2 | 2 |
Patient 3 | 1 | 1 | 1 | 1 | 1 | 1 |
Patient 4 | 2 | 3 | – | – | – | – |
Patient 5 | 4 | 2 | 4 | 3 | 2 | 3 |
Mean (SD) | 2.2 (1.8) | 1.6 (1.1) | 2.5 (1.7) | 2.8 (1.7) | 1.8 (0.5) | 2.0 (0.8) |
NPI-Q | ||||||
Patient 1 | 0 | 0 | 0 | 2 | 27 | 6 |
Patient 2 | 0 | 0 | 0 | 0 | 0 | 16 |
Patient 3 | 0 | 1 | 1 | 0 | 1 | 2 |
Patient 4 | 0 | 3 | – | – | – | – |
Patient 5 | 2 | 1 | 0 | 0 | 0 | 0 |
Mean (SD) | 0.4 (0.9) | 1.0 (1.2) | 0.3 (0.5) | 0.5 (1.0) | 7.0 (13.3) | 6.0 (7.1) |
ADCS | ||||||
Patient 1 | 63 | 64 | 62 | 65 | 66 | 68 |
Patient 2 | 64 | 65 | 61 | 64 | 62 | 49 |
Patient 3 | 67 | 62 | 66 | 69 | 58 | 66 |
Patient 4 | 72 | 66 | – | – | – | – |
Patient 5 | 76 | 72 | 75 | 72 | 75 | 70 |
Mean (SD) | 68.4 (5.5) | 65.8 (3.8) | 66.0 (6.4) | 67.5 (3.7) | 65.3 (7.3) | 63.3 (9.6) |
