Fig. 2
Whole-blood transcriptional gene signatures in TB. a Heatmaps depicting unsupervised hierarchical clustering of active TB (red), LTBI (black) and control samples (purple) using a 373-gene signature derived using the Berry London cohort, tested in the Berry South Africa cohort, and b validated in an independent cohort from Leicester. Gene expression values were averaged and scaled across the row to indicate the number of standard deviations above (red) or below (blue) the mean, denoted as row Z-score. c Bar graphs depicting enrichment scores derived on a single sample basis using ssGSEA in the Berry London, Berry South Africa and Leicester cohorts using the 16-gene signature from Zak et al.32. Purple, black and red bars represent control, LTBI and active TB samples, respectively, and * (control outliers), # (LTBI outliers) and § (active TB outliers) represent the outlier samples identified by hierarchical clustering
