Fig. 3
From: Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
ISO-1 inhibits IL-1β in response to Plasmodium falciparum. a–c Viable human PBMCs collected from three donors were co-cultured with 2 × 106 non-infected or CS2-infected RBC. Cells were either treated with DMSO alone (control) or with increasing concentrations of ISO-1 (5, 25, or 50 µM) for 16 h. Levels of IL-1β in cell culture supernatants were quantified by ELISA. d Percentage inhibition calculated for all three donors ± SEM ***P < 0.005, ****P < 0.001, one-way ANOVA with a correction provided by the Tukey's multiple comparisons test
