Fig. 3 | Nature Communications

Fig. 3

From: Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Fig. 3

Validation of metrics assessing NK cell inter- and intra-individual diversity. a, c Donor-to-donor expression variation (DEV) and b, d inverse Simpson diversity index (SDI) were calculated as described for a cohort of healthy individuals (n = 202) grouped according to (a, b) CMV and b EBV serostatus, as well as (c, d) in intrahepatic NK cells (n = 9) compared with peripheral blood NK cells from healthy controls (n = 13). Mann–Whitney (SDI) and Wilcoxon test (DEV) were used for statistical analysis. Bars indicate median values, *p < 0.05 and **p < 0.01, ****p < 0.0001

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