Fig. 6 | Nature Communications

Fig. 6

From: Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Fig. 6

The necrosome recruits hMLKL via RIPK3 before RIPK3-mediated phosphorylation induces hMLKL reorganization and/or disengagement, membrane translocation, and necroptotic death. a A revised model for MLKL activation. Human MLKL relies on recruitment to the necrosome via RIPK3, which scaffolds assembly of necroptotic MLKL tetramers and their reorganization and/or disengagement following RIPK3-mediated phosphorylation. b In contrast to mouse MLKL, which can be activated by mutations that mimic RIPK3-mediated phosphorylation, hMLKL activity is compromised by pseudoactive site and activation loop mutations

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