Fig. 5
From: DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Two-sample Mendelian randomization (MR). a The top plot shows the effect size from the eQTL analysis (outcome, n = 156, blue) in the PBMC cohort for the SNPs included in the MR. The middle and bottom plots (red) show the effect sizes from the meQTL analysis (exposure, n = 279, red) in the blood cohort for DMR3 and DMR4, respectively, for the SNPs included in the MR. The location of two regions is marked with a dashed line. Further details are given in Methods. b Scatterplots of the effect sizes for meQTL (x-axis) and eQTL (y-axis) for DMR3 (left) and DMR4 (right). The effect size and the 95% confidence intervals are shown. The blue line represents the causal estimate using the Egger regression. All the associations with the exposures were set to be positive and the associations with the outcome were re-oriented
