Fig. 3
From: UBXN3B positively regulates STING-mediated antiviral immune responses
UBXN3B is critical for type I IFN responses to SeV and VSV, but not EMCV infection. a The survival curves of Ubx3b−/− (N = 6) and Ubxn3b−/− (N = 7) mice infected with 1 × 107 PFU of VSV i.v. The results are pooled from two experiments. *P < 0.05 (log-rank test). b, c qPCR analysis of Ifnb1 expression in cDCs infected with b VSV (MOI = 5) or c SeV (200 hemagglutination units per 105 cells). d ELISA of IFN-α in the cell culture supernatants of cDCs infected with SeV and VSV as in b, c. N = 3 per genotype per time point. *P < 0.05 (unpaired Student’s t test). e The survival curves of Ubx3b+/+ (N = 7) and Ubxn3b−/− (N = 8) mice infected with 200 PFU of EMCV i.p. P = 0.53 (log-rank test). The results are pooled from two experiments. f qPCR analysis of Ifnb1 expression in cDCs infected with EMCV (MOI = 5) for the indicated time. Bars/data points: mean ± s.e.m. Two biological replicates were pooled for qPCR (N = 2 per genotype per time point). *P < 0.05 (unpaired Student’s t test). The results are representative of two independent experiments
