Fig. 3 | Nature Communications

Fig. 3

From: PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Fig. 3

Heatmap showing overlapping loci between four traits. For each locus associated with PR interval, we tested the strength of the association and direction of effect for three related traits: QRS duration, atrial fibrillation, and heart rate. While the genetic bases of these three traits show a distinct overlap with that of PR interval, we observe for each trait overlapping loci with both concordant and discordant associations, with some variants that prolong PR interval prolonging QRS duration or increasing heart rate (concordant associations), whereas others shorten QRS duration or decrease heart rate. Similarly, some variants that prolong PR interval increase AF risk (concordant association) while others decrease AF risk (discordant).  Red color indicates concordant association with increasing PR associated with increasing QRS, or higher risk of AF, or higher HR. Blue color indicates discordant association of shortened QRS, or lower risk of AF, or lower HR.  Intensity of color indicates significance of association: GWA (GWAS significant association), Bonf (Bonferroni corrected significance), Nom (nominal significance), NS (not significant) 

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