Table 2 Description of novel PR loci among those of European descent

From: PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

European ancestry index SNPs in novel PR loci

Non-red SNPs

AA PR

Missense

Cardiac DHS

Cardiac eQTL

Locus

SNP

Chr

Closest gene

CA

CAF

Beta (ms)

SE (ms)

P-value

n

P < 0.05

r2 > 0.8

r2 > 0.8

FDR < 0.05

11

rs4648819

1

SKI

G

0.11

−1.7

0.28

4.68E−10

1

–

–

–

–

12

rs7538988

1

EPS15

C

0.03

−2.1

0.37

1.14E−08

1

–

–

YES

–

13

rs12127701

1

MYBPHL

G

0.06

1.7

0.28

1.54E−09

1

–

MYBPHL

–

–

14

rs11264339

1

KRTCAP2

T

0.48

−0.7

0.11

5.94E−10

1

–

EFNA1

YES

–

15

rs397637

1

OBSCN

T

0.28

0.8

0.12

7.11E−10

1

–

OBSCN

YES

–

16

rs3856447

2

ID2

A

0.39

1.2

0.11

1.20E−26

2

–

–

YES

–

17

rs2732860

2

TMEM182

G

0.52

−0.9

0.11

3.03E−15

2

–

–

YES

TMEM182

18

rs13018106

2

FIGN

C

0.42

−0.8

0.12

1.53E−11

1

YES

–

YES

–

19

rs922984

2

TTN

T

0.07

1.5

0.23

1.79E−11

2

–

TTN

YES

–

20

rs9826413

3

EOMES

T

0.06

2

0.36

1.69E−08

1

–

–

–

–

21

rs900669

3

FRMD4B

A

0.25

0.8

0.13

5.71E−09

1

YES

–

YES

–

22

rs13087058

3

PDZRN3

C

0.37

−1

0.12

5.82E−17

1

–

–

YES

–

23

rs16858828

3

PHLDB2

C

0.18

0.9

0.15

2.41E−08

1

–

–

YES

–

24

rs6441111

3

CCNL1

C

0.52

0.8

0.13

6.96E−11

1

YES

–

YES

LINC00881

25

rs7638853

3

SENP2

A

0.34

−0.7

0.12

2.44E−08

1

–

SENP2

YES

–

26

rs17446418

4

CAMK2D

G

0.26

0.8

0.13

3.41E−09

1

–

–

YES

–

27

rs3733409

4

FAT1

T

0.13

0.9

0.17

2.67E−08

1

YES

FAT1

YES

FAT1

28

rs7729395

5

PAM

T

0.05

2.4

0.37

1.00E−10

1

–

PAM

–

–

29

rs11763856

7

TBX20/HERPUD2

T

0.03

3.1

0.49

4.47E−10

2

YES

–

YES

–

30

rs2129561

7

MKLN1

A

0.42

−1

0.12

3.39E−15

1

–

–

–

LINC-PINT

31

rs881301

8

FGFR1

C

0.41

0.8

0.12

5.04E−10

1

–

–

YES

–

32

rs12678719

8

ZFPM2

G

0.27

0.8

0.13

3.77E−10

1

–

–

–

–

33

rs12359272

10

ALDH18A1/SORBS1

A

0.37

1

0.13

3.68E−16

2

–

–

YES

–

34

rs12257568

10

SH3PXD2A/OBFC1

T

0.41

1

0.12

5.83E−18

2

YES

–

–

–

35

rs1372797

11

NAV2

T

0.12

−1.1

0.18

2.36E−09

2

–

–

YES

–

36

rs11067773

12

MED13L

C

0.09

−1.3

0.23

1.02E−08

1

–

–

–

–

37

rs718426

13

EFHA1

G

0.41

−1.2

0.11

3.25E−24

1

–

–

YES

–

38

rs2585897

13

XPO4

A

0.16

1.2

0.15

9.28E−16

1

YES

–

YES

–

39

rs9590974

13

LRCH1

C

0.34

1.1

0.12

1.02E−19

1

–

–

YES

–

40

rs11465506

14

IL25/MYH6

A

0.02

−6.4

1.04

7.06E−10

2

YES

MYH6

YES

–

41

rs4901308

14

FERMT2

T

0.19

−0.8

0.15

2.04E−08

1

–

–

–

–

42

rs17767398

14

SNORD56B SIPA1L1

G

0.26

1

0.13

6.44E−13

1

–

–

YES

–

43

rs904974

15

TLE3

T

0.16

1.1

0.19

4.53E−08

1

YES

–

–

–

44

rs1984481

17

MYOCD

C

0.54

−0.8

0.12

1.37E−11

1

–

–

YES

–

  1. For each of the 34 novel loci, we list the number of non-redundant signals, whether this locus is nominally significant in African Americans, if missense SNPs are in LD with the index SNP, if the index SNP is in LD with or located in a cardiac DHS, and if the locus contains cardiac or blood eQTLs
  2. Chr chromosome, CA coded allele, CAF coded allele frequency, SE standard error, Non-red SNPs non-redundant SNPs
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