Fig. 4 | Nature Communications

Fig. 4

From: The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

Fig. 4

Calmodulin- and calmodulin kinase II-dependent nuclear accumulation of DDX3X. a Confocal immunofluorescence images of DDX3X (magenta) in HeLa cells overexpressing TRPV4-V5 and DDX3X-Myc. Nuclei were stained with DAPI (blue). Colocalization of DDX3X and nuclei is shown in white in the merge panels. b Mean± SEM nuclear/total DDX3X ratio determined under the experimental conditions indicated. The number of cells analyzed for each condition is indicated in each bar. The data are means ± SEM. ***P < 0.001 when comparing isotonic control with any other condition as determined by non-parametric Krustal–Wallis followed by Dunn’s post hoc test. Scale bar = 10 μm

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