Fig. 7
From: The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

Model of the interaction between TRPV4 and DDX3X to regulate viral RNA metabolism. In the absence of external stimulation TRPV4 anchors both DDX3X and CaM. Following the activation of TRPV4 by viruses (or other physiological/pharmacological stimuli), DDX3X disengages from the channel and shuttles to the nucleus in a CaM/CaMKII-dependent process. In the nucleus, DDX3X facilitates the exit of unspliced viral RNA via de Rev/CRM1 export system. In the cytoplasm, DDX3X facilitates translation of viral RNA. Altogether, the interplay between TRPV4 and DDX3X promotes viral replication