Fig. 4 | Nature Communications

Fig. 4

From: Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

Fig. 4

Limited change in mean heteroplasmy with maternal age in oocytes and pups. Transformed heteroplasmy change (Eq. 4) between reference measurement and oocyte or pup samples in LE (a, b) and HB (c, d) models, as a function of maternal age. Gradients of lines correspond to model parameter β. Datapoints give the mean heteroplasmy change from a sampled set (set of oocytes, or litter) ± s.e.m. Fit lines are mean and 95% c.i.s for simple linear model fit (c.i.s from bootstrapping with the percentile method) of all individuals within all samples, for each dataset independently. b, d show a shift between oocyte heteroplasmy dynamics and pup heteroplasmy dynamics

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