Fig. 5

Germline heteroplasmy variance increases with organismal age. The cell-to-cell variance in oocyte heteroplasmy increases as a mouse ages; the pup-to-pup variance in litter heteroplasmy increases with the age of the mother. Datapoints give mean normalised heteroplasmy variance with estimated standard errors (see text); fits presented are both a naive linear fit to the mean variance statistics, and a weighted fit (mean and 95% c.i.s) with bootstrapping accounting for variability in the measured heteroplasmy variance statistics (hence penalising the samples with large errorbars)