Fig. 6

Heteroplasmy statistics evolve during ageing, development, and between generations. a Joint inference of the model behaviour given the full, combined set of our heteroplasmy observations. An offset decrease in mean heteroplasmy and a linear increase in heteroplasmy variance, suggested by Figs 3 and 4, are clearly observed. Insets show how the inferred behaviour corresponds to the mechanistic parameters in our stochastic model. Shaded regions correspond to 95% c.i.s on summary statistics; the corresponding intervals for individual heteroplasmy measurements are shown in Supplementary Figure 4. b Bootstrapped distributions of the parameter values in our model given data from LE and HB mice