Fig. 7
From: Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Rebalancing histone acetylation rescues cognitive deficits in 6-month old Fmr1 KO mice. a Experimental scheme for assessing cognitive functions in WT and Fmr1 KO mice with concurrent TMZ and various chemicals treatments. b Schematic of novel location test for assessing spatial learning. c–h Concurrent TMZ treatment prevents Curcumin- (c–e) (n = 8 to 13 mice per group) or Nutlin-3-induced (d–h) (n = 8 to13 mice per group) improvement of spatial memory in Fmr1 KO mice in the novel location test. Total exploration time (d, g) and percentage exploration time (e, h) of novel location test are shown. i Schematic of the novel object recognition test. j–o Concurrent TMZ treatment prevents curcumin-(j–l) (n = 8 to 14 mice per group) or Nutlin-3-induced (m–o) (n = 8 to 12 mice per group) improvement of novel object recognition in Fmr1 KO mice. Total exploration time (k, n) and percentage exploration time (l, o) of novel object recognition test are shown. *P < 0.05, **P < 0.01, ***P < 0.001, n.s.: no significant difference. Two-way ANOVA was used for all data analyses. Data are presented as mean ± s.e.m.
