Fig. 8
From: Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Heterozygote deletion of MDM2 in Nestin-expressing adult NSCs and new neurons rescues cognitive deficits of 6-month-old Fmr1 KO mice. a Experimental scheme for assessing cognitive function transgenic mice followed by TAM injection. b–e Heterozygote deletion of MDM2 in Nestin-expressing adult NSCs and new neurons fully rescues spatial learning deficits in Fmr1 KO mice (n = 7 to 11 mice per group). f–i Heterozygote deletion of MDM2 in Nestin-expressing adult NSCs and new neurons fully rescues novel object recognition in Fmr1 KO mice (n = 7 to 11 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001, n.s.: no significant difference. Two-way ANOVA was used for all data analyses. Data are presented as mean ± s.e.m.
