Fig. 9
From: Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Rebalancing histone acetylation rescues cognitive deficits in 6-month-old Fmr1 cKO;Cre;Ai14 mice. a Experimental scheme for assessing cognitive functions in mice and Cre;Ai14 control mice, followed by TAM injection and various chemical treatments. b–e Curcumin or Nutlin-3 treatment rescues spatial learning deficits in Fmr1 cKO;Cre;Ai14 as mice determined by novel location test (n = 7 to 10 mice per group). Total exploration time (d) and percentage exploration time (e) of novel location test are shown. f–i Curcumin or Nutlin-3 treatment fully rescues deficits in the novel object recognition in Fmr1 cKO;Cre;Ai14 mice (n = 7 to 10 mice per group). Total exploration time (h) and percentage exploration time (i) of novel object recognition test are shown. *P < 0.05, **P < 0.01, ***P < 0.001, n.s.: no significant difference. Two-way ANOVA was used for all data analyses. Data are presented as mean ± s.e.m.
