Fig. 4 | Nature Communications

Fig. 4

From: Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice

Fig. 4

WES analysis of somatic mutations in blood/tissue pairs from FCD II patients. a The pre-surgery brain T1 and T2 MRI images of two FCD II subjects showing the lesion sites (arrows). H&E staining of pathological samples showed dysmorphic and cytomegalic neurons (balloon cells) (arrows). b Flow chart of the WES pipeline and data analysis by the Virmid and MuTect algorisms. DP, Read depth, AC, alternative allele counts. c Overlap of gene mutations found in human FCD patients, genes involved in neural development from IPA analysis and genes validated using RNAi

Back to article page