Fig. 5
Combination therapy partially rescues systemic infection of G. mellonella by high FoG C. albicans isolates. a G. mellonella larvae were injected with 3 × 105 yeast cells/larvae followed by a second injection with either PBS, FLC alone, or FLC and FNZ within 90 min of the first injection. b–d Survival curves of larvae infected with SC5314 (b), low FoG (c) and high FoG (d) isogenic derivatives. Each curve represents a group of 24 larvae (n = 24) which were monitored daily for survival for up to 14 days after infection. P values represent results of log-rank test comparing different treatment conditions with significance values as follows: ***P < 0.001; **P < 0.01; *P < 0.05; ns nonsignificant
