Fig. 1 | Nature Communications

Fig. 1

From: KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary

Fig. 1

Mutational landscape of primary and recurrent aGCTs. a Somatic mutation rate per megabase (Mb) for primary (n = 8) and recurrent (n = 16) aGCTs. Gray bars indicate samples with no matched normal tissue, for which the mutation rate may be inflated by the inclusion of rare SNPs. b Time in years between diagnosis, first recurrence (blue arrow), and sample collection (red circle). The receipt of cytotoxic chemotherapy at any time between diagnosis and sample collection is indicated by an orange box. c Significantly mutated genes in aGCT. d Significantly recurrent focal CNVs. e Recurrent arm-level CNVs. Heat map indicates log CN ratio for CNV event. Mb: megabases, CN: copy number

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