Fig 3

Error trials reveal sensitivity of PPC to both stimulus and choice. Only Hit-preferring neurons were used in all panels of this figure. a Trial-averaged responses during False Alarm (FA) trials, for recordings with at least five FA trials, in V1 (left; 1053 neurons across 16 sessions) and in PPC (right; 3034 neurons across 21 sessions). Responses for each neuron are normalized by peak response across Correct Reject (CR, left, blue), FA (center, dark blue), and Hit trials (right, red). Neurons are sorted by descending strength of FA response. Vertical dashed lines demarcate duration of stimulus. b Population trial-averaged responses (top) during Hit, FA (dashed), and CR trials, for V1 (left) and PPC (right). Average lick rate (bottom). c Violin plots (rotated histograms) of selectivity index for V1 (left) and PPC (right) neurons, computed using stimulus-period responses. Three comparisons were made for each neuron in each area (Hit > CR, Hit > FA, FA > CR, see Supplementary Table 1). Horizontal lines indicate mean, and colored bars indicate neurons with significant individual modulation (p < 0.05). d Average selectivity between trial types, computed separately at each time-point. Colored bars at top indicate time points with significant non-zero selectivity (p < 0.05, clustered Wilcoxon signed-rank test). e Percentage of neurons with significant (p < 0.05) positive selectivity at each time-point. Shading indicates mean ± SEM across sessions. Dotted line indicates the expected percentage by chance