Fig. 3 | Nature Communications

Fig. 3

From: TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Fig. 3

TMEM106B induces synthesis of increased number and size of lysosomes. a–c Human or mouse lung cancer cells induced to express either GFP as control, or GFP-tagged TMEM106B were imaged as indicated. (1) Cells imaged in bright field show enlarged vesicular structures formed upon expression of TMEM106B. (2–5) Cells were incubated with LysoTracker stain and counter stained with Hoechst33342, imaged live in real time as indicated. TMEM106B-expressing cells form enlarged lysosomes that stain positive for LysoTracker. Magnified fields exhibit the stained vesicles

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