Table 1 Participant characteristics of lung cancer cases and controls in GWAS cohorts
Variants | 1st Discovery cohort (n = 3900) | 2nd Discovery cohort (n = 6573) | Replication Cohort (n = 32,465) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control (n = 1977) | Case (n = 1923) | P-value | Control (n = 3578) | Case (n = 2995) | P-value | Control (n = 14,026) | Case (n = 18,439) | P-value | |||||||
No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||||
Age (years) | |||||||||||||||
0–64 | 502 | 25.4 | 420 | 21.8 | 0.009 | 2304 | 64.39 | 1825 | 60.9 | 0.004 | 8449 | 60.2 | 9513 | 51.6 | <0.0001 |
≥65 | 1475 | 74.6 | 1503 | 78.2 | 1274 | 35.61 | 1170 | 39.1 | 5577 | 39.8 | 8926 | 48.4 | |||
Gender | |||||||||||||||
Male | 1514 | 76.6 | 1520 | 79.0 | 0.06 | 2417 | 67.55 | 2093 | 69.9 | 0.04 | 8639 | 61.6 | 11,495 | 62.3 | 0.37 |
Female | 463 | 23.4 | 403 | 21.0 | 1161 | 32.45 | 902 | 30.1 | 5384 | 38.4 | 6941 | 37.6 | |||
Omitted | 3 | 0.02 | 3 | 0.02 | |||||||||||
Smoking status | |||||||||||||||
Never | 633 | 32.0 | 138 | 7.1 | <0.0001 | 867 | 24.23 | 137 | 4.6 | <0.0001 | 4415 | 31.5 | 1800 | 9.8 | <0.0001 |
Ever | 1339 | 67.7 | 1774 | 92.3 | 2702 | 75.52 | 2854 | 95.3 | 9930 | 66.5 | 16,341 | 88.6 | |||
Omitted | 5 | 0.3 | 11 | 0.6 | 9 | 0.25 | 4 | 0.1 | 281 | 2.0 | 298 | 1.6 | |||
Histology | |||||||||||||||
Squamous | 488 | 25.4 | 307 | 10.3 | 4490 | 24.3 | |||||||||
Adenocarcinoma | 788 | 40.9 | 620 | 20.7 | 6819 | 37.0 | |||||||||
Other | 613 | 31.9 | 226 | 7.5 | 5487 | 29.8 | |||||||||
Omitted | 34 | 1.8 | 1842 | 61.5 | 1643 | 8.9 | |||||||||
