Table 2 Index SNPs in the chromosome 15q25.1 locus which were associated with lung cancer with P < 5.00E-8 in the 1st discovery cohort and in meta-analysis of the discovery cohorts

From: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

SNP

Gene

Predicted function

A1

A2

1st discovery cohort

2nd discovery cohort

Meta-analysis of discovery cohorts

replication cohort

     

P-value

BONFa

P-value

BONFa

P-value

BONFa

P-value

BONFa

rs1051730

CHRNA3

coding

T

C

2.28E-14

7.77E-11

3.03E-13

1.04E-09

1.64E-25

5.09E-20

3.11E-49

1.06E-45

rs1996371

CHRNB4

intronic

G

A

9.08E-12

3.10E-08

1.15E-05

3.93E-02

2.05E-14

6.36E-09

2.83E-24

9.65E-21

rs6495314

CHRNB4

intronic

C

A

1.47E-11

5.01E-08

7.29E-06

2.49E-02

1.47E-14

4.56E-09

8.54E-24

2.91E-20

rs8034191

HYKK

intronic

C

T

3.05E-11

1.04E-07

8.98E-14

3.07E-10

2.40E-23

7.45E-18

2.12E-46

7.23E-43

rs11638372

CHRNB4

intronic

T

C

3.14E-10

1.07E-06

2.95E-05

1.01E-01

8.11E-13

2.52E-07

5.28E-24

1.80E-20

rs2036534

HYKK

3downstream

C

T

3.81E-10

1.30E-06

4.29E-06

1.47E-02

7.81E-14

2.42E-08

4.85E-32

1.65E-28

rs4887077

CHRNB4

intronic

T

C

4.16E-10

1.42E-06

2.39E-05

8.17E-02

7.72E-13

2.40E-07

2.23E-23

7.61E-20

rs6495309

CHRNB4

3downstream

T

C

3.57E-08

1.22E-04

4.29E-06

1.47E-02

2.18E-12

6.76E-07

9.34E-29

3.19E-25

  1. aP-value was adjusted for multiple comparisons using Bonferroni correction.
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