Table 3 Pathways and GO terms in discovery and replication with a threshold of FDR < 0.25 in both phase

Source	Pathway/gene set name	Meta-analysis of discovery cohorts		Replication cohort
Source	Pathway/gene set name	P-value	FDR	P-value	FDR
KEGG	neuroactive ligand receptor interaction	0.001	0.006	0.013	0.042
Reactome	neuronal system	0.001	0.015	0.014	0.082
	transmission across chemical synapses	0.003	0.023	0.003	0.028
Gene Oncology	substrate-specific channel activity	<0.001	0.005	0.002	0.004
	ion channel activity	<0.001	0.005	0.002	0.004
	substrate-specific transporter activity	0.001	0.006	0.010	0.013
	cation channel activity	0.002	0.006	0.002	0.008
	ion transmembrane transporter activity	0.002	0.006	0.004	0.009
	metal ion transmembrane transporter activity	0.001	0.006	0.002	0.003
	transmembrane transporter activity	<0.001	0.006	0.007	0.012
	gated channel activity	0.002	0.006	0.001	0.016
	substrate-specific transmembrane transporter activity	<0.001	0.006	0.006	0.012
	cation transmembrane transporter activity	0.001	0.006	0.003	0.006
	transmembrane receptor activity	0.001	0.007	<0.001	0.006
	receptor activity	0.017	0.021	0.002	0.007
	macromolecular complex	0.001	0.008	0.006	0.037
	protein complex	0.001	0.012	0.006	0.080
	intrinsic to membrane	0.003	0.022	0.002	0.025
	intrinsic to plasma membrane	0.004	0.024	0.002	0.030
	integral to membrane	0.003	0.027	0.002	0.027
	membrane part	0.005	0.028	0.013	0.050
	membrane	0.006	0.032	0.024	0.071
	plasma membrane part	0.009	0.032	0.005	0.030
	integral to plasma membrane	0.003	0.035	0.002	0.051
	plasma membrane	0.015	0.044	0.034	0.085

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