Table 5 Individual and combined effects of SNPs from our susceptibility pathways on lung cancer risk in the meta-analysis of Discovery Cohorts

From: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

  

Univariate analysis

Multivariate analysis*

  

OR

L95

U95

P

P_trend

OR

L95

U95

P

P_trend

CHRNA3

 rs1051730

0

1

   

1.29E-25

    

2.68E-24

1

1.31

1.21

1.43

3.46E-10

 

1.32

1.21

1.44

1.23E-09

 

2

1.86

1.65

2.09

8.80E-25

 

1.89

1.67

2.14

7.44E-24

 

CHRNB4

 rs6495309

0

1

   

2.35E-12

    

4.56E-11

1

1.22

1

1.5

0.05

 

1.21

0.98

1.49

0.08

 

2

1.58

1.3

1.93

5.21E-06

 

1.56

1.27

1.91

2.67E-05

 

KCNJ4

 rs138396

0

1

   

0.06

    

0.04

1

1

0.91

1.09

0.94

 

1.01

0.92

1.1

0.89

 

2

1.13

1.01

1.26

0.03

 

1.15

1.02

1.29

0.02

 

SCN2B

 rs7944321

0

1

   

0.07

    

0.14

1

1.07

0.98

1.16

0.13

 

1.06

0.97

1.15

0.19

 

2

1.12

0.94

1.34

0.22

 

1.09

0.91

1.32

0.35

 

neuroactive ligand receptor interaction pathway

(CHRNA3 rs1051730 and CHRNB4 rs6495309)

 

0-1

1

   

2.80E-26

1

   

1.55E-24

 

2

1.32

1.18

1.47

8.45E-07

 

1.32

1.18

1.48

1.82E-06

 
 

3

1.48

1.32

1.65

4.94E-12

 

1.47

1.31

1.65

6.14E-11

 
 

4

2.04

1.79

2.33

2.22E-26

 

2.07

1.8

2.38

4.99E-25

 

gated channel activity term

(CHRNA3 rs1051730, CHRNB4 rs6495309, KCNJ4 rs138396 and SCN2B rs7944321)

 

0-1

1

   

4.39E-19

    

2.46E-18

 

2-3

1.29

1.08

1.53

5.50E-03

 

1.3

1.08

1.56

5.50E-03

 
 

4-5

1.6

1.34

1.9

1.84E-07

 

1.63

1.36

1.96

1.65E-07

 
 

6-8

2.15

1.74

2.65

9.31E-13

 

2.17

1.74

2.7

4.01E-12

 
  1. *Adjusted by age sex smoke status in the Logistic Models.
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