Table 6 Individual and combined effects of SNPs from our susceptibility pathways on lung cancer risk in Replication Cohort

From: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

  

Univariate analysis

Multivariate analysis*

  

OR

L95

U95

P

P_trend

OR

L95

U95

P

P_trend

CHRNA3

 rs1051730

0

1

   

1.70E-51

1

   

1.82E-44

1

1.28

1.22

1.34

3.43E-23

 

1.27

1.21

1.33

2.62E-20

 

2

1.65

1.54

1.77

2.47E-46

 

1.63

1.52

1.75

1.22E-40

 

CHRNB4

 rs6495309

0

1

   

1.40E-29

1

   

1.55E-24

1

1.14

1.02

1.28

0.02

 

1.12

1

1.26

0.05

 

2

1.46

1.31

1.63

1.32E-11

 

1.42

1.27

1.6

2.13E-09

 

KCNJ4

 rs138396

0

1

   

2.00E-04

1

   

5.00E-04

1

1.06

1.01

1.11

0.03

 

1.05

1

1.11

0.08

 

2

1.13

1.06

1.21

2.00E-04

 

1.13

1.06

1.21

4.00E-04

 

SCN2B

 rs7944321

0

1

   

8.90E-03

1

   

0.01

1

1.06

1.01

1.11

0.026

 

1.05

1

1.11

0.04

 

2

1.1

0.99

1.22

0.083

 

1.1

0.99

1.23

0.08

 

neuroactive ligand receptor interaction pathway

(CHRNA3 rs1051730 and CHRNB4 rs6495309)

 

0-1

1

   

1.11E-58

1

   

4.80E-50

 

2

1.21

1.14

1.28

1.79E-09

 

1.21

1.14

1.29

2.96E-09

 
 

3

1.44

1.36

1.54

1.44E-30

 

1.42

1.33

1.52

2.43E-26

 
 

4

1.77

1.64

1.91

2.65E-49

 

1.74

1.61

1.89

3.32E-43

 

gated channel activity term

(CHRNA3 rs1051730, CHRNB4 rs6495309, KCNJ4 rs138396 and SCN2B rs7944321)

 

0-1

1

   

3.36E-44

1

   

2.09E-37

 

2-3

1.18

1.07

1.3

8.00E-04

 

1.15

1.04

1.28

5.40E-03

 
 

4-5

1.51

1.37

1.67

4.89E-17

 

1.47

1.33

1.63

7.77E-14

 
 

6-8

1.79

1.59

2.02

2.84E-22

 

1.72

1.52

1.95

8.27E-18

 
  1. *Adjusted by age sex smoke status in the Logistic Model
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