Fig. 5
From: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
RH works in large animals and ex vivo human lungs. a Adsorption efficiency of nanogels onto various species’ RBCs. Each data point represents mean ± s.e.m (n = 3 replicates per condition). b Live pigs were injected with I-125-labeled nanogels that were either free or RH. Plotted are the lung-to-liver and lung-to-blood ratios. Each data point represents mean ± s.e.m (n = 3 pigs per condition). c Safety in pigs was assessed by showing that Cr51-labeled RBCs used in the RH experiments of b did not get stuck in the lungs. d, e Ex vivo human lungs were endovascularly cannulated and then infused through a single artery sequentially with: I-125-labeled RH nanogels; I-131-labeled free nanogels; and a green tissue dye. The percent of the injected dose of the entire lung lobe (e, left panel) and within only the well-perfused (green) zone (e, right panel, where ten 2-mL volumes of lung were measured and their mean ± s.e.m. listed on the plot). *P < 0.05, two-tailed t-test
