Fig. 1
From: UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
UTX acts as an ‘escape from X-inactivation tumor-suppressor’ during Eμ-Myc-induced lymphomagenesis. a Expression level of UTX in human lymphoma were correlated with risk and overall survival time. UTX expression status was used as the variable to test if it can predict patient survival. Green and red lines indicated low-risk (n = 298) and high-risk (n = 116) groups, respectively. Risk grouping was conducted through an optimization algorithm. Analysis was performed by SurvExpress. High-risk group was correlated with low expression of UTX. b Distribution of male and female patients in risk groups separated by UTX expression. Male were enriched in low expression of UTX indicated low risk, poor prognosis. Female were enriched in high expression of UTX indicated low risk, good prognosis. c Kaplan–Meier curves indicating the survival of male mice with each cohort, UTX−/y mice (n = 19,black), Eμ-Myc;UTX+/y mice (n = 9, red), Eμ-Myc;UTX−/y mice (n = 30, blue). d Kaplan–Meier curves indicating the survival of female mice with each cohort, UTX−/− mice (n = 19, black), Eμ-Myc mice (n = 30, red), Eμ-Myc;UTX−/+ mice (n = 15, green), Eμ-Myc;UTX−/− mice (n = 16, blue). e Comparison of Kaplan–Meier curves of Eμ-Myc;UTX−/− and Eμ-Myc;UTX−/y. f Comparison of Kaplan–Meier curves of Eμ-Myc;UTX−/y and Eμ-Myc;UTX+/−. Statistical significance was determined using log-rank test for panel C to F. g Distribution of B cell differentiation stages for lymphomas from each genotype
