Fig. 3 | Nature Communications

Fig. 3

From: Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Fig. 3

Organoids have a shared genomic landscape with patient-matched tumors. a Copy number alterations of selected receptor tyrosine kinases and key downstream pathway mediators are highlighted in tumors and corresponding organoids. b Structural variants affecting the top recurrently rearranged genes described in Secrier & Li et al.13 and c Structural variants are compared between tumor and organoid. d Circos plots depicting all mutations (plotted based on inter-mutational distance), copy number changes, and structural variants in the genomes of tumor CAM277 and matched organoid

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