Fig. 8
From: HIV-1 targets L-selectin for adhesion and induces its shedding for viral release
Immunogold-labeled budding HIV viruses. Examples of TEM images of HIV-1LAI-infected Rev-CEM cells labeled with 10 nm gold particle conjugated anti-CD62L (FMC46) in the absence (a, b) and presence (c, d) of BB-94. Arrows point to the gold-labeled CD62L. Gold particles were generally visible on infected T cells near but not associated with HIV budding virions (a, b) in the absence of BB-94. In the presence of BB-94, however, a significant number of budding virions are observed directly associated with gold particles, suggesting the tethering of the budding virions by L-selectin (c, d). The images are representatives of at least five similar images in each category. Scale bars are 200 nm
