Fig. 5
In vivo biodistribution and pharmacokinetic profile. a Blood circulation time of the Cy5.5-labeled IPA/LDH, the fluorescence intensity of Cy5.5 in the blood was determined over time after intravenous injection. b Time-dependent NIR fluorescence images of Hela tumor-bearing mice at 0 h, 0.5 h, 1 h, 2 h, 4 h, 8 h, 12 h, and 24 h post-injection. c Fluorescence images of heart (H), liver (Li), spleen (S), lung (Lu), kidney (K), and tumor (T) harvested from mice after intravenous injection of Cy5.5-labeled IPA/LDH at different time points. d Quantitative biodistribution analysis of the IPA/LDH in mice by measuring the Cy5.5 fluorescence intensity at different time points post-injection. Error bars were defined as standard deviation, n = 3
