Fig. 8 | Nature Communications

Fig. 8

From: SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

Fig. 8

Proposed model for SUMO2-PCNA-mediated TRC resolution. a Simultaneous interactions of RECQ5 with RNAPIIo and PCNA induce PCNA SUMO2 conjugation. Black lines represent DNA. Purple double arrows indicate protein–protein interactions. Single dashed arrows present histone chaperone activity. b SUMOylated PCNA enriches CAF1 and FACT in the replication complex to deposit repressive histones and reduce chromatin accessibility. Stars represent SUMO2. See text for details

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