Table 1 Clinical and phenotypic features of patients with Cushing’s disease

Characteristics	Wild-type (n = 55)	BRAF V600E (n = 15)	P value	USP48 mutation (n = 21)	P value
Gender
Male	16	4	0.856^a	3	0.187^a
Female	39	11		18
Age at diagnosis
Median	36	36	0.769^b	41	0.5^b
Interquartile range	27–46	26–46		26.5–49.5
Clinical course
Median	36	24	0.438^b	12	0.06^b
Interquartile range	12–84	8–60		3.5–48
Diameter (mm)
Median	10	7.5	0.502^b	8.5	0.437^b
Interquartile range	5–22	3.5–22		6.4–10
Midnight plasma corticotropin (ACTH) (pg/ml)
Median	60.4	140.5	0.023^b	48.45	0.307^b
Interquartile range	49.05–107.47	82.15–220.04		31.57–92.63
Midnight serum cortisol (μg/dl)
Median	17.5	23.82	0.007^b	17.7	0.673^b
Interquartile range	14.34–28.05	21.82–39.10		13.74–33.88
Urinary free cortisol (μg/24 h)
Median	510.97	488.94	0.936^b	415.66	0.505^b
Interquartile range	273.69–1133.15	405.37–1116.78		215.28–894.86
Invasiveness
Yes	13	2	0.546^a	4	0.816^a
No	39	10		14
Immediate postoperative biochemical remission (%)
Yes	24	6	0.951^a	13	0.328^a
No	25	6		8
Postoperative recurrence (%)
Yes	2	1	0.937^a	0	0.224^a
No	9	4		8

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