Table 2 Pathways with a significant effect (Pcorrected < 0.05) on broad depression following multiple testing correction identified through gene-set enrichment analysis
Phenotype | Pathway | Number of genes | Beta (St. Err.) | P -value | P Corrected |
|---|---|---|---|---|---|
Broad depression | GO_EXCITATORY_SYNAPSE | 184 | 0.342 (0.069) | 3.45 × 10−7 | 0.003 |
GO_POSTSYNAPSE | 354 | 0.248 (0.050) | 3.88 × 10−7 | 0.003 | |
GO_NEURON_SPINE | 115 | 0.390 (0.089) | 2.72 × 10−6 | 0.019 | |
GO_DENDRITE | 425 | 0.200 (0.044) | 3.08 × 10−6 | 0.021 | |
GO_MECHANOSENSORY_BEHAVIOR | 12 | 1.270 (0.294) | 8.04 × 10−6 | 0.047 |
