Fig. 6
From: Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Human carriers of apoE4 isoform present a more activated immune profile as compared to carriers of the wild-type apoE3 isoform. a–c Plasma levels of total cholesterol (a), LDL-cholesterol (b) and triglycerides (c) from human carriers of apoE isoforms. d–i Percentage of circulating TEM (CD45RA-CCR7lo) (d), Tnaive (CD45RA + CCR7hi) (f) and TCM (CD45RA-CCR7hi) (h) CD4+ in carriers of the different apoE isoforms; representative dot plots are reported (e, g, i). j Graphic representation of mixed lymphocyte reaction (MLR) by CD4+ T naïve cells stimulated with monocyte-derived DCs (MDCs) pulsed with LPS (1 µg/mL for 2 days) from human carriers of apoE isoforms. k Polarization of CD4+ T cells after MLR between mature MDCs and syngenic T naive cells. N = 6 per group (k). Statistical analysis was performed with two-way Anova. Data are reported as mean ± SEM; *p < 0.05, **p < 0.01
