Table 6 Top variants from novel loci discovered in multiethnic meta-analysis of FEV₁/FVC^a in the CHARGE consortium

Nearest gene(s)^b,c	Top variant	Chr:Pos	Coded allele^d	Allele freq	N	Beta^e	SE	P value
DCAF8	rs11591179	1:160206067	t	0.45	90,624	−0.002	0.0003	3.48E−08
KCNJ3, NR4A2	rs72904209	2:157046432	t	0.88	90,453	0.003	0.0005	3.09E−08
RBMS3	rs28723417	3:29431565	a	0.74	90,358	0.002	0.0004	1.77E−08
DCBLD2, MIR548G	rs80217917	3:99359368	t	0.88	90,617	−0.003	0.0005	2.58E−08
AFAP1	rs28520091	4:7846240	t	0.44	80,715	0.002	0.0004	8.40E−09
LINC00340	rs9350408	6:22021373	t	0.51	82,761	−0.003	0.0003	7.45E−14
FLJ35282, ELAVL2	rs10965947	9:23588583	t	0.39	90,475	0.002	0.0004	2.70E−09
TMEM38B, ZNF462	rs2451951	9:109496630	t	0.47	88,436	0.002	0.0003	2.36E−08
JMJD1C	rs75159994	10:64916064	t	0.77	86,988	−0.003	0.0004	6.09E−09
HTRA1	rs2293871	10:124273671	t	0.23	90,481	0.002	0.0004	1.51E−08
FAM168A	11:73280955: GA_G	11:73280955	d	0.20	55,521	0.004	0.0006	2.74E−08
DDHD1, MIR5580	rs4444235	14:54410919	t	0.54	80,712	0.002	0.0004	4.03E−08
TSHZ3	rs9636166	19:31829613	a	0.86	80,714	0.003	0.0005	3.25E−09
KLHL22, MED15	rs4820216	22:20854161	t	0.13	82,714	−0.003	0.0005	2.61E−10

^aPhenotype: ratio FEV₁/FVC (as a proportion).
^bNearest gene: indicates gene either harboring the variant or nearest to it. HTRA1 locus also includes DMBT1. JMJD1C locus also includes EGR2, NRBF2, JMJD1C-AS1, REEP3. KLHL22/MED15 locus also includes ZNF74, SCARF2.
^cLoci also discovered in European ancestry meta-analyses (Table 2): RBMS3, AFAP1, LINC00340, TSHZ3, KLHL22/MED15.
^dAlleles for INDELS: I insertion, D deletion.
^eAdditive effect of variant on pulmonary function, adjusting for age, age², sex, height, height², smoking status, pack-years of smoking, weight (for FVC only), and center, ancestral principal components, and a random familial effect to account for family relatedness when appropriate

Quick links

Search