Table 1 Sample description

From: Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia

Variable

Cases

Controls

Comparison

Subjects after quality control

135

137

N/A

Male sex, N (%)

92 (68.2%)

73 (53.3%)

\(\chi _1^2\) = 6.30, P = 0.012

European ethnicity, N (%)a

112 (83.0%)

98 (71.5)

\(\chi _3^2\) = 7.92, P = 0.048

Age at death, mean (SD)

73.3 (12.6)

73.9 (17.7)

F1,271 = 0.09, P=0.76

Postmortem brain pH, mean (SD)

6.47 (0.24)

6.50 (0.25)

F1,234=0.88, P=0.35

Postmortem brain mass (g), mean (SD)

1207 (173)

1155 (166)

F1,269=6.46, P=0.012

Postmortem interval (h), mean (SD)

24.3 (15.7)

10.9 (7.6)

F1,270=80.2, P < 0.0001

RNA integrity number, mean (SD)

7.11 (0.79)

7.57 (0.84)

F1,270=21.5, P < 0.0001

Unique aligned reads (×106), mean (SD)

89.12 (17.0)

89.80 (16.1)

F1,270 = 0.12, P = 0.73

Normalized peak calls (FDR 0.01), mean (SD)

117.3 (70.1)

130.4 (61.6)

F1,270=2.66, P=0.10

  1. All samples were from Brodmann area 9 of left hemisphere
  2. aAdditional ethnicities in cases were African American (17, 12.6%), Hispanic (5, 3.7%), and Asian (1, 0.74%), and in controls African American (20, 14.6%), Hispanic (16, 11.7%), and Asian (3, 2.2%). The RNA-based measure is pertinent for the DNA-based ATAC-seq assay as the samples were from the same aliquots