Fig. 6
From: Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
Blnc1 inactivation ameliorates diet-induced NASH. a Blnc1 expression in mice fed chow (n = 3) or NASH (n = 3) diet for 6 months. Data represent mean ± SEM. ***p < 0.001, chow vs. NASH, two-tailed unpaired Student’s t-test. (b–d) Plasma lipids (b), liver weight, TAG and cholesterol content (c) and plasma ALT and AST levels (d) in ctrl (filled, n = 6) and LKO (open, n = 6) mice fed NASH diet for 24 weeks. e H&E and Sirius red staining of liver sections. Scare bar = 100 μm. f Liver hydroxyproline content and quantitation of Sirius red-positive area in e. g TUNEL staining and quantitation (scale bar = 100 μm). Data in (b–d), (f) and (g) represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Ctrl vs. LKO, two-tailed unpaired Student’s t-test
